Glutamate weighted imaging contrast in gliomas with 7 Tesla magnetic resonance imaging

A Neal; BA Moffat; JM Stein; RPR Nanga; P Desmond; RT Shinohara; H Hariharan; R Glarin; K Drummond; A Morokoff; P Kwan; R Reddy; TJ O'Brien; KA Davis

Journal article

Glutamate weighted imaging contrast in gliomas with 7 Tesla magnetic resonance imaging

A Neal, BA Moffat, JM Stein, RPR Nanga, P Desmond, RT Shinohara, H Hariharan, R Glarin, K Drummond, A Morokoff, P Kwan, R Reddy, TJ O'Brien, KA Davis

Neuroimage Clinical | ELSEVIER SCI LTD | Published : 2019

DOI: 10.1016/j.nicl.2019.101694

Download PDF

Abstract

Introduction: Diffuse gliomas are incurable malignancies, which undergo inevitable progression and are associated with seizure in 50–90% of cases. Glutamate has the potential to be an important glioma biomarker of survival and local epileptogenicity if it can be accurately quantified noninvasively. Methods: We applied the glutamate-weighted imaging method GluCEST (glutamate chemical exchange saturation transfer) and single voxel MRS (magnetic resonance spectroscopy) at 7 Telsa (7 T) to patients with gliomas. GluCEST contrast and MRS metabolite concentrations were quantified within the tumour region and peritumoural rim. Clinical variables of tumour aggressiveness (prior adjuvant therapy and ..

View full abstract

University of Melbourne Researchers

Bradford Moffat Author

Patricia Desmond Author

Rebecca Glarin Author

Kate Drummond Author

Related Projects (4)

Brain tumors and seizures

Seizures commonly develop in patients with brain tumours. Despite tumour resection, patients continue to experience seizures. Furthermore, p..

RADIOLOGICAL AND MOLECULAR FEATURES CORRELATING WITH SEIZURES IN PATIENTS WITH SUPRATENTORIAL GLIOMAS

Brain tumors and seizures

Seizures commonly develop in patients with brain tumours. Despite tumour resection, patients continue to experience seizures. Furthermore, p..

The molecular basis of tumour-associated epilepsy

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This work was supported by National Institutes of Health grant P41 EB015893 (NIBIB), K23-NS073801-01 and the Royal Melbourne Hospital Neuroscience Foundation. Dr. Andrew Neal was supported by an Australian Government Research Training Program Scholarship, and a Miriam Greenfield Research Establishment Fellowship. 7 T scanning was supported by the Melbourne node of the Australian National Imaging Facility supported under the NCRIS program. We also acknowledge support from the Farber and Thornton Foundations.